1 Prilosec OTC pill each morning lets you block heartburn for 24 hrs.* Heartburn occurs when stomach acid refluxes into the esophagus, causing discomfort. Prilosec OTC's omeprazole allows the active ingredient, omeprazole, to pass through stomach acid to prevent excess acid production providing lasting heartburn relief.* Other heartburn relief treatments only neutralize acid after it's produced, offering shorter relief lasting less than 24 hrs. Prilosec OTC heartburn medicine stands out; unlike traditional antacids omeprazole blocks acid production providing powerful heartburn relief that antacids can't match. Take control of your comfort with Prilosec OTC omeprazole. Experience the difference that daily use of omeprazole heartburn medicine can make in your life.* It is possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. May take 1 to 4 days for full effect. Not for immediate relief. Compared to how antacids work for heartburn. Use all heartburn medications as directed. IQVIA ProVoice Survey, 2005-2022.^ *Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill a day & use as directed for 14 days to treat frequent heartburn. May take 1 to 4 days for full effect.